ALKOR PLUS 10/20MG 14 TAB

الوصف

Type: Tablets

Company: HIKMA PHARMA , EGYPT

Use: Antihyperlipidemic

Active constituent : EZETIMIBE+SIMVASTATIN

About Ezetimibe
Cholesterol Absorption Inhibitor, 2-Azetidinone derivative, Hypolipidemic agent.
Mechanism of Action of Ezetimibe
It reduces the absorption of cholesterol from the intestine by localising at the brush border of the small intestine, where it inhibits the absorption of cholesterol from the diet. Specifically, it appears to bind to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelium, a critical mediator of cholesterol absorption. This decreased cholesterol absorption leads to an increase in LDL-cholesterol uptake into cells, thus decreasing levels in the blood plasma.
Indications for Ezetimibe
1. Adjunct to dietary measures and statin in primary and homozygous familial hypercholesterolaemia
2. Adjunct to dietary measures in homozygous familial sitosterolaemia
Interactions for Ezetimibe
Cyclosporin: Plasma concentraction of ezetimibe increased. Lipid-regulating drugs: Avoid concomitant use with fibrates.

About Simvastatin
Statins, HMG-CoA reductase inhibitor, A hypolipidemic agent.
Mechanism of Action of Simvastatin
It is a precursor lactone converted in to active form in the body which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It increases high density lipoprotein (HDL) levels than other statins